Manuel Lanzini's tenth-minute goal was to prove the difference in a tense game that saw United boss Ole Gunnar Solskjaer throw in the likes of Mason Greenwood and Fernandes late on to try and change the momentum of the game.
It was the first Old Trafford triumph for the Hammers since Carlos Tevez's matchwinner in 2007 keeping them in the Premier League and their first in a cup competition. Hilarious memes have been doing rounds on the internet after the exit and below are some.
The Red Devils will hope to pick themselves up as fast as possible as they have another tricky test against Aston Villa coming up on Saturday with the English giants currently joint top of the Premier league together with Chelsea and Liverpool.
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