Both clubs qualified for the Champions League semi-finals in midweek, with Thomas Tuchel's side defeating Porto 2-1 on aggregate and Pep Guardiola ending his quarter-final hoodoo with a commanding 4-2 victory over Borussia Dortmund over two legs.
Sergio Aguero, City's all-time leading goalscorer and a soon-to-be free agent, prefers to play Chelsea more than any other player, but due to his current muscular problem, the Argentine will not be able to add to his 15 goals against the Blues.
Aguero, on the other hand, is the only player in City's medical room after Aymeric Laporte was healthy enough to start against Dortmund, and the Frenchman could replace John Stones in Guardiola's back four once more.
After a midweek rest, Joao Cancelo is expected to return to the backline, with Oleksandr Zinchenko expected to make room on the left flank. If Kyle Walker is benched, Benjamin Mendy could be recalled and Cancelo could play on the right, but the Englishman will undoubtedly start a game of this magnitude.
Kevin De Bruyne has nine goals in his last eight FA Cup games, and he'll be back in the engine room alongside Rodri and Ilkay Gundogan, but the final third is where Guardiola's real problems lie.
Gabriel Jesus, who has already scored twice in this season's tournament, will hope to be trusted from the start. Raheem Sterling has been benched more than once in recent weeks, and Foden does not deserve to be demoted. Zack Steffen will start in goal ahead of Ederson, according to Guardiola.
Manchester predicted lineup is as follows:
Steffen; Walker, Dias, Laporte, Cancelo; Rodri, Gundogan, De Bruyne; Mahrez, Jesus, Foden
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