Opera News

Opera News App

How to Deal with Methanol Poisoning

Cyrus@pharmacytimes
By [email protected] | self meida writer
Published 29 days ago - 17 views

Methanol poisoning, though not frequent nowadays is a serious form of toxicity that is associated with chronic ingestion of methanol, an alcohol.

Methanol when taken orally has a long latency period and symptoms appear after several hours from the time of ingestion. In the body, methanol is metabolised in the liver by enzymes called Liver alcohol dehydrogenases which also breaks down ethanol (a component of alcoholic beverages).

[Alcoholic beverages, photo courtesy of drinkszones.com]

Products of metabolism are formaldehyde and further oxidation leads to formation of formic acid. Formic acid is the one responsible for the optic nerve toxicity, thus, leading to irreversible blindness.

When noted earlier and immediate intervention made, there is complete reversal of this poisoning. Several approaches to detoxify methanol include use of drugs such as, ethanol, Fomepizole and aldehyde dehydrogenase inhibitors.

Ethanol which is common in spirits, vodka, gin etc can be given orally or intravenously to treat methanol poisoning. Both are metabolism by the same enzyme in the liver with Ethanol having a higher affinity for the enzyme compared to methanol.

[photo courtesy of wellRx.com]

Fomepizole, a drug that is available in the market as an injection, acts by inhibiting Liver alcohol dehydrogenase enzyme. This is implies that the methanol is not metabolised at all in the body and is excreted unchanged.

[photo courtesy of drugs.com]

Aldehyde dehydrogenase inhibitors inhibits aldehyde dehydrogenase enzyme hence formaldehyde is not converted to the toxic formic acid.

Content created and supplied by: [email protected] (via Opera News )

Tags:      

Methanol
Opera News is a free to use platform and the views and opinions expressed herein are solely those of the author and do not represent, reflect or express the views of Opera News. Any/all written content and images displayed are provided by the blogger/author, appear herein as submitted by the blogger/author and are unedited by Opera News. Opera News does not consent to nor does it condone the posting of any content that violates the rights (including the copyrights) of any third party, nor content that may malign, inter alia, any religion, ethnic group, organization, gender, company, or individual. Opera News furthermore does not condone the use of our platform for the purposes encouraging/endorsing hate speech, violation of human rights and/or utterances of a defamatory nature. If the content contained herein violates any of your rights, including those of copyright, and/or violates any the above mentioned factors, you are requested to immediately notify us using via the following email address operanews-external(at)opera.com and/or report the article using the available reporting functionality built into our Platform

YOU MAY LIKE

Kabando Wa Kabando Alleges Why The State Is Trying To Draw Raila Closer

1 hours ago

22 🔥

Kabando Wa Kabando Alleges Why The State Is Trying To Draw Raila Closer

"Maintaining the Current Fuel Prices is Absurd and Immoral" Sen Omanga Says as She Recommends This

1 hours ago

2 🔥

Peter Kenneth Reveals What Uhuru Must do if He is to be Respected by Mt Kenya Region as 2022 Nears

1 hours ago

483 🔥

Peter Kenneth Reveals What Uhuru Must do if He is to be Respected by Mt Kenya Region as 2022 Nears

Seven Cities In Africa That Have Not Developed Fast

1 hours ago

2 🔥

Seven Cities In Africa That Have Not Developed Fast

Never Say These Words While In Court: May Land You In Trouble

1 hours ago

38 🔥

Never Say These Words While In Court: May Land You In Trouble

Selina Tv Drama is Coming to an End

1 hours ago

72 🔥

Selina Tv Drama is Coming to an End

"Contain Raila and Block Ruto" Kabando Wa Kabando Sends Chilling Reply to Jeff Koinange

1 hours ago

1433 🔥

New Details Emerge on Why The Court Will Not Be Accepting Laurence Warunge's Guilty Plea Tomorrow

1 hours ago

140 🔥

New Details Emerge on Why The Court Will Not Be Accepting Laurence Warunge's Guilty Plea Tomorrow

Ruto's Condolence Message to a Boda guy Lights up the Internet

1 hours ago

22 🔥

Ruto's Condolence Message to a Boda guy Lights up the Internet

"Am The Most Intelligent MP In Kenya" Babu Owino Brags

1 hours ago

10 🔥

COMMENTS