The Vice President's speech will, however, be read by a representative, whom his communications team describes as "a respectable person in society."
The identity of Ruto's representative at the conference remains hidden.
In the past, it was traditional for the president to officially open the three-day devolution conference and for his deputy to close the convention on the last day.
This year's devolution conference, which is the 7th and last under the Jubilee administration, is being held at Makueni Boys High School.
During the function, the 47 governors come together to review the performance and challenges of the previous year, and chart a course for the betterment of their constituents.
In addition to the governors, Chief Justice Martha Koome is among the prominent figures who spoke at this year's convention.
Koome, in his speech on Thursday, November 25, said no one should be worried about his role in the 2022 polls team, stating that judicial independence runs deep and cannot be threatened by his inclusion in the intergovernmental election preparation team.
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