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Study: Combining an AstraZeneca Dose With Pfizer, 4 Weeks Apart, Gives Strong Immunity

Combining a dose of Covid-19 vaccines from Pfizer Inc. and AstraZeneca Plc creates a strong immune response, based on research from the University of Oxford, a finding that could allow more flexibility in the use of fewer devices.

The mixed schedule of Pfizer ammunition followed by the Astra vaccine, and vice versa, resulted in high levels of antibodies to Covid-19 when given four weeks apart, researchers in the Lancet medical journal reported on Monday.

Doctors and public health officials have analyzed various ways to expand vaccine distribution - by delaying the time between the first and second test, for example - many low- and middle-income countries are trying to figure out how to manage the vaccine. vaccine. shortages. The possibility of combining doses can help countries with different immunization facilities to help each other.

The mechanism by which people received the vaccines affected the results. Astra followed by Pfizer provided higher levels of immune cells and T cells than Pfizer followed by Astra.

The study found that the two combined vaccination schedules required more antibodies than the two doses of Astra. The best components of the adaptive immune system (T cell) response came from Astra followed by Pfizer, and the highest antibody response was seen from two doses of Pfizer.

"This is due to the flexibility in using these times, where local conditions require it," Matthew Snape, an Oxford professor who led the case, told a press conference. "It gives everyone a choice."

Access and vaccine effectiveness has been widened by the fact that the AstraZeneca vaccine is currently split into 12 weeks in the UK. In addition, an Oxford study published on Monday showed that shrinkage shots for as long as 10 months improved response even more. Results of a 12-week mixed dose test will be available "within a month or so," Snape told the conference.

The trial involved 830 volunteers aged 50 and over and tested these vaccines only against the first Wuhan dialect identified. Additional testing against additional coronavirus strains could be helpful in explaining which vaccines and combinations to use in winter supplementation in the winter, Snape said. Further research from the program will examine the combination of vaccines from Moderna Inc and Novavax Inc.

Last month, an earlier study of these found that the Pfizer and Astra mixing rates increased side effects, such as fatigue and headaches but not severe, for the results of the Lancet study indicated that these would just be mild effects.

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AstraZeneca AstraZeneca Plc Lancet Pfizer University of Oxford


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