The people in the world have lived to witness most the dangerous pandemic over the years. This have threaten the sanity and survival of human races. Hundreds of thousands people have perish over the years. But the two pronounced worst pandemics ever in the based on the magnitude of the deaths are as follows.,
The Plague of Justinian
The plague of justinian or Justinianic Plague (541–549 AD) was the beginning of the first plague pandemic, the first Old World pandemic of plague, the contagious disease caused by the bacterium Yersinia pestis . The disease afflicted the entire Mediterranean Basin ,and Europe,
Near East, severely affecting the Sasanian Empire and the Roman Empire and especially its capital, Constantinople .The plague is named for the Roman emperor in Constantinople, Justinian I (r. 527–565) who, according to his court historian Procopius , contracted the disease and recovered in 542, at the height of the epidemic which killed about a fifth of the population in the imperial capital.
The contagion arrived in Roman Egypt in 541, spread around the Mediterranean Sea until 544, and persisted in Northern Europe.
The phrase 'black death' – describing Death as black – is very old. Homer used it in the
Odyssey to describe the monstrous Scylla , with her mouths "full of black Death" ( Ancient Greek :
πλεῖοι μέλανος Θανάτοιο, romanized : pleîoi mélanos Thanátoio).Seneca the Younger may have been the first to describe an epidemic as 'black death', ( Latin : mors atra ) but only in reference to the acute lethality and dark.
prognosis of disease. The 12th–13th century French physician Gilles de Corbeil had already used atra mors to refer to a "pestilential fever" ( febris pestilentialis) in his work On the Signs and Symptoms of Diseases ( De signis et symptomatibus aegritudium).
The phrase mors nigra , 'black death', was used in 1350 by Simon de Covino (or Couvin), a Belgian astronomer, in his poem "On the Judgement of the Sun at a Feast of Saturn" (De judicio Solis in convivio Saturni), which attributes the plague to an astrological conjunction of Jupiter and Saturn. His use of the phrase is not connected unambiguously with the plague pandemic of 1347 and appears to refer to the fatal outcome of disease.
The historian Cardinal Francis Aidan Gasquet wrote about the Great Pestilence in 1893  and suggested that it had been "some form of the ordinary Eastern or bubonic plague". [c] In 1908, Gasquet claimed that use of the name
atra mors for the 14th-century epidemic first appeared in a 1631 book on Danish history by
J. I. Pontanus: "Commonly and from its effects, they called it the black death" (Vulgo & ab effectu atram mortem vocitabant ).
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