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Khat Drug Long Term Side Effects.

Khat can cause many side effects including mood changes, increased alertness, excessive talkativeness, hyperactivity, excitement, aggressiveness, anxiety, elevated blood pressure, manic behavior, paranoia, and psychoses. Trouble sleeping (insomnia), loss of energy (malaise), and lack of concentration usually follow.

In the body, khat can increase blood pressure and heart rate, like other stimulants. Using khat a lot or over a long period of time can cause tooth decay, gum disease, and heart problems. It can also cause problems with your stomach and digestive tract, such as constipation, ulcers, pain, and tumors.

In terms of adverse psychological effects, khat can contribute to such conditions as depression, anxiety, mood instability, and mania. There have also been some case reports of drug-induced psychosis, and, in individuals with established psychotic disorders, khat use may lead to an increased risk of relapse.

How Long Does Khat Stay in Your System? Once consumed, the effects of khat peak after approximately 15 to 30 minutes. The drug has a half-life of approximately three hours.

Chronic (i.e., daily) use of khat is associated with increased blood pressure, development of gastrointestinal tract problems, cytotoxic effects on liver and kidneys, and keratotic lesions at the side of chewing.

Khat administration induced a significant reduction in sperm motility and sperm count but led to an increase in abnormal sperm chromatin integrity without affecting sperm volume and sperm pH.

The results suggest that high-dose khat decreases sperm quality and testosterone and hence may contribute to male infertility.

Severe side effects include migraine, bleeding in the brain, heart attack, lung problems, liver damage, changes in intimacy drive, and inability to get an erection (impotence). Chewing khat leaves has led to infections that can cause problems such as pain below the ribs, changes in white blood cells, and an enlarged liver.

It was clear from the available studies that khat reduces body weight in the rat animal model. The reduction of body weight was sustained in studies that used high doses or long durations. Small doses produced a short-term reduction of weight followed by the tolerance of the effect.

Khat leaves contain cathinones, an active brain stimulant that is similar in structure and pharmacological activity to amphetamines. Like amphetamines, Khat ingestion in low doses results in decreased appetite, euphoria, increased intellectual efficiency, and hyperalertness.

As a medicine, khat leaf is used for depression, fatigue, obesity, stomach ulcers, and male infertility. It is also used to lower the need for food and sleep, decrease intimacy desires, and increase aggression.

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