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The usage of the most expensive liquid. A drop at 130dollars.

The venom of the yellow scorpion without a doubt. It can sell for up to $ 39 million a gallon. But even with the money, you couldn't buy the gallon, you could just buy a drop for $ 130. Getting a gallon of this liquid is not an easy task. Scorpions are milked by hand, and a scorpion at most produces 2 milligrams of venom at a time. You would have to milk 2.6 million times to get one gallon. But why is this liquid so expensive?. A scorpion's venom is a mixture of compounds, including neurotoxins that affect the victim's nervous system. Stings from dangerous species may cause paralysis, severe convulsions, cardiac irregularities, breathing difficulties, and even death. Antivenins are available in areas where dangerous scorpions live. It has numerous medical usage;

•For the treatment of Rheumatoid Arthritis [*]

•For the treatment of fetal alcohol spectrum disorder [*]

•Can kill staph and tuberculosis bacteria,

•For Cancer-related researches,

•Can help detect the brain tumours,

•Can also be used as a painkiller,

•Helps prevent organ rejection during transplant,

•Could lead to completely new antibiotics.

The truth is that every time the venom of this scorpion is investigated, more uses are found for it, therefore, the more valued it is and the demand for this appreciated liquid continues to increase progressively. The Peptides and Proteins Lab at the Institute for Research in Biomedicine has discovered the capacity of a small protein, found in scorpion venom, to carry drugs across the blood–brain barrier. They have studied the efficiency of these compounds in cell models of the BBB and have demonstrated that the peptide called MiniCTX3 has the capacity to transport compounds of different nature across the BBB with great efficiency.

Chlorotoxin, a small protein found in scorpion venom (Giant Yellow Israeli scorpion), can be used to carry drugs across the blood–brain barrier (BBB), which is highly selective in order to protect the brain from toxic substances. But also prevents many potential therapeutic drugs from reaching the brain, contributing to the difficulty of treating neurological diseases and brain tumours.Section of the brain showing normal part of the brain and blood brain barrier (BBB), and part of the brain infiltrated with GBM (Glioblastoma is the most common and the most aggressive primary malignant tumor of the central nervous system.) Blood vessels are enclosed by endothelial cells connected with tight junctions which seal the intercellular space and prevent entrance of drugs from the blood stream to the brain. BBB is further reinforced with a basal lamina. While basal lamina is disrupted by GBM tumor cells (left figure), endothelial cells are still present forming blood brain tumor barrier (BBTB). Nanoparticles loaded with drugs and coated with receptors specific to the tumor vasculature and glioma cells can interact with the BBTB allowing for transcytosis and delivery of the drugs to GBM tumor cells.

Content created and supplied by: BigThiNkerClues (via Opera News )


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